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| Name and address | License | Places |
|---|---|---|
| Sacred Heart Academy Preschool 4895 Saratoga Avenue | Preschool center | 75 |
| Sagebrush Children's Center 6801 Easton Court | Preschool center | 72 |
| Saint Michael Preschool 2637 Homedale Street | Preschool center | 100 |
| San Carlos United Methodist Weekday Preschool 6554 Cowles Mountain Boulevard | Preschool center | 122 |
| San Diego City College Early Education Center 1313 Park Boulevard | Preschool center | 44 |
| San Diego Cooperative Preschool 4190 Front Street | Preschool center | 59 |
| San Diego Jewish Academy Preschool 11860 Carmel Creek Road | Preschool center | 120 |
| Santa Sophia Preschool 9800 San Juan Street | Preschool center | 60 |
| Say Jerabek Preschool Center 10050 Avenida Magnifica | Preschool center | 28 |
| Say San Diego Early Childhood Center 4775 Viewridge Avenue | Preschool center | 24 |
| School of the Madeleine Preschool 1930 Illion Street | Preschool center | 45 |
| Scripps Exploring Academy 9855 Erma Road, Suite 128 | Preschool center | 166 |
| Scripps Montessori School 9939 Old Grove Road | Preschool center | 122 |
| Seaside Preschool 1201 Turquoise Street | Preschool center | 60 |
| Sherman State Preschool/Head Start Program 301 22nd Street | Preschool center | 24 |
| Silverman Preschool of Tifereth Israel Synagogue 6660 Cowles Mountain Boulevard | Preschool center | 89 |
| Soille San Diego Hebrew Day School 3630 Afton Road | Preschool center | 100 |
| Solana Beach CDC - Solana Ranch Preschool 13605 Pacific Highlands RCH PK | Preschool center | 48 |
| Sorrento Valley Children's Center 4050 Sorrento Valley Blvd. #A | Preschool center | 84 |
| Sorrento Valley Kindercare 10068 Pacific Heights Blvd. | Preschool center | 98 |
| SRSRC - Scripps Trail Children's Center 10250 Scripps Trail | Preschool center | 46 |
| St Gregory the Great Catholic Preschool 15315 Stonebridge Parkway | Preschool center | 63 |
| St. Andrew's Lutheran Preschool 8350 Lake Murray Boulevard | Preschool center | 24 |
| St. Charles Catholic Preschool 980 Saturn Boulevard | Preschool center | 48 |
| St. Columba Preschool 3365 Glencolum Drive | Preschool center | 60 |
| St. Didacus School 4639 Felton Street | Preschool center | 30 |
| St. Mark's Weekday Nursery School 3502 Clairemont Drive | Preschool center | 94 |
| St. Patrick Preschool 3583 30th Street | Preschool center | 29 |
| St. Paul's Community Care Center 328 Maple Street | Preschool center | 54 |
| St. Paul's Lutheran Church & School 1376 Felspar Street | Preschool center | 52 |
| St. Peter's Preschool 1371 Sunset Cliffs Boulevard | Preschool center | 50 |
| St. Rita's School 5165 Imperial Ave. | Preschool center | 42 |
| St. Therese Academy Pre-K 6440 Saint Therese WAY | Preschool center | 60 |
| St. Vincent De Paul Village Preschool Program 1501 Imperial Avenue | Preschool center | 86 |
| St. Vincent Preschool 4077 Ibis Street | Preschool center | 65 |
| Stone Ranch Elementary School Preschool 16150 4S Ranch Parkway | Preschool center | 69 |
| Sundance Elementary School 8944 Twin Trails Drive | Preschool center | 24 |
| Tesoro Preschool 3030 Thorn Street | Preschool center | 48 |
| The Exploring Children's Academy 10850 Montongo Street | Preschool center | 24 |
| The Kid's Bay 13770 Carmel Valley Road | Preschool center | 133 |
| The Rock Academy Early Education Center 2277 Rosecrans Street | Preschool center | 125 |
| Timbertoy Bilingual Montessori LLC 6736 Linda Vista RD | Preschool center | 43 |
| TLC Preschool 11240 Clairemont Mesa BLVD | Preschool center | 12 |
| Toby Wells YMCA Developmental Preschool 5105 Overland Avenue | Preschool center | 95 |
| Tsumiki 4811 Mount Etna Drive | Preschool center | 40 |
| Urban Village 1 Early Learning Academy 3795B Fairmount Avenue | Preschool center | 80 |
| Valencia Park Early Learning Academy 5880 Skyline Drive | Preschool center | 19 |
| Waldorf School of San Diego 3547 Altadena Avenue | Preschool center | 83 |
| Walker's Children's Center 9245 Hillery Drive | Preschool center | 48 |
| Warren-Walker Early Learning Center 2905 Cadiz Street | Preschool center | 12 |
| Warren-Walker School - Ocean Beach 4605 Point Loma Avenue | Preschool center | 60 |
| Wee Care Early Learning Center 3580 Mount Acadia Boulevard | Preschool center | 170 |
| Westview High Preschool 13500 Camino Del Sur | Preschool center | 60 |
| Westwood Club Preschool Program 17394 W Bernardo DR | Preschool center | 90 |
| Willow Grove Preschool 14727 Via Azul | Preschool center | 48 |
| World of Wonders Preschool 2051 Sunset Cliffs Blvd | Preschool center | 23 |